- Diane Abbott was the first black woman elected to the British Parliament.
- Angel Allen – first Black woman to hold FFA [ Future Farmers of America] title
- Maame Biney became the first black woman to qualify for a U.S. Olympic speedskating team
- Candice Bridge – the first black female to teach chemistry at Howard University
- Dr. Joye Carter – the first black female Chief Medical Examiner
- Sherrie Eugene-Hart – the First Black Woman in the UK to qualify as a British Sign Language Interpreter
- Lori Patton Davis – the first African-American woman to lead the Association for the Study of Higher Education (ASHE).
- Thasunda Duckett – the first African American to be CEO of JP Morgan & Chase Consumer Banking
- Roxane Gay is the first Black woman to write for Marvel Comics
- Dr. Hadiyah-Nicole Green – the first person to successfully cure cancer in mice using laser-activated nanoparticles.
- Dr. Nadine Burke Harris – California’s first-ever Surgeon General
- Janice Bryant Howroyd – the first to own and operate a billion-dollar company in the U.S.
- Angela James – considered one of the first superstars of women's hockey
- Wanda James – the first legally licensed African American and veteran-owned cannabis dispensary
- Hattie Leeper the first African-American woman on Disc Jockey in Charlotte, N.C radio in the 1950’s
- Evelyn Magley – made history as the first African American woman to ever own a male professional sports league in the United States.
- Jessica Nabongo – a UN employee turned travel blogger, it's by becoming the first black woman of African descent to visit every country on Earth and document it.
- Danielle Outlaw – the first black woman to be Portland's police chief
- Sharron Parks – First Black Woman to Serve as Sworn Newnan Police Department Officer in March of 1986
- DJ Poizon Ivy – ". . . the second-ever female NBA team DJ and, in 2018, became the first woman to DJ the NBA All-Star Game." Forbes
- Barbara Proctor – the first African American woman to own and operate an advertising agency
- Mariyah Russell – the first Black woman to be awarded a Michelin star
- Briana Scurry first black woman elected to National Soccer Hall of Fame
- Bessie Stringfield – the first Jamaican-American woman to ride across the United States solo